L6295

Lomerizine dihydrochloride

≥98% (HPLC), powder

• Synonyme(s) : 1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride
• Formule empirique (notation de Hill) : C₂₇H₃₀F₂N₂O₃·2HCl
• CAS Number: 101477-54-7
• Poids moléculaire : 541.46
• Numéro MDL: MFCD01703867
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817637
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥30 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.Cl.COc1ccc(CN2CCN(CC2)C(c3ccc(F)cc3)c4ccc(F)cc4)c(OC)c1OC
• InChI: 1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H
• Clé InChI: LOGVKVSFYBBUAJ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator.

Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H410
• Conseils de prudence: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable