L7795

Levocetirizine dihydrochloride

≥98% (HPLC)

• Synonyme(s) : Levocetirizine dihydrochloride, (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
• Formule empirique (notation de Hill) : C₂₁H₂₅ClN₂O₃·2HCl
• CAS Number: 130018-87-0
• Poids moléculaire : 461.81
• Numéro MDL: MFCD07366507
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817657
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Solubilité: H₂O: ≥23 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1
• Clé InChI: PGLIUCLTXOYQMV-GHVWMZMZSA-N
• Informations sur le gène: human ... HRH1(3269)

Description

Description générale

Levocetirizine dihydrochloride is the R-enantiomer of cetirizine and is used for treating seasonal allergic rhinitis and chronic idiopathic urticaria. The liver metabolizes 14% of levocetirizine and rest is excreted in urine. The response of levocetirizine to histamine is comparatively higher to cetirizine.

Application

Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.

Actions biochimiques/physiologiques

Levocetirizine dihydrochloride is a nonsedating type histamine H1-receptor antagonist; active isomer of cetirizine

Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.

Caractéristiques et avantages

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H400
• Conseils de prudence: P273 - P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable