L9919

LY2033298

≥98% (HPLC)

• Synonyme(s) : 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide
• Formule empirique (notation de Hill) : C₁₃H₁₄ClN₃O₂S
• CAS Number: 886047-13-8
• Poids moléculaire : 311.79
• Numéro MDL: MFCD12912423
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817677
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: off-white to tan
• Solubilité: DMSO: >20 mg/mL
• Auteur: Eli Lilly
• Température de stockage: −20°C
• Chaîne SMILES: COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
• InChI: 1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)
• Clé InChI: CTEGQKDJTBWFHW-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

LY2033298 is a positive allosteric modulator of muscarinic M4 receptor.

LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 potentiates ACh-M4 binding, with no effect at M1/3/5 receptors. LY2033298 can also bind to the M ACh receptor, and mediate either positive or negative allosteric effects depending on the ligand used to probe receptor activity.

Caractéristiques et avantages

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H334
• Conseils de prudence: P261 - P284 - P501
• Classification des risques: Resp. Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable