M0418

Melanin

Synthetic, BioReagent, suitable for cell culture

• CAS Number: 8049-97-6
• Numéro CE : 232-473-6
• Numéro MDL: MFCD00131581
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: synthetic
• Gamme de produits: BioReagent
• Essai: ≥97% (TLC)
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Solubilité: 1 N NH₄OH: 20 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: [nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O
• InChI: 1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
• Clé InChI: XUMBMVFBXHLACL-UHFFFAOYSA-N

Description

Description générale

Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds.

Application

Melanin has been used:

• to incubate normal human keratinocytes for Masson-Fontana staining
• as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes
• as an absorber to mimic human skin or melanocytic nevi and melanoma

Actions biochimiques/physiologiques

Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture.

Notes préparatoires

Prepared by oxidation of tyrosine with hydrogen peroxide.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)