M4910

1-Methylhistamine dihydrochloride

≥98% (TLC), powder

• Synonyme(s) : 1-Methyl-4-(β-aminoethyl)imidazole dihydrochloride
• Formule empirique (notation de Hill) : C₆H₁₁N₃ · 2HCl
• CAS Number: 6481-48-7
• Poids moléculaire : 198.09
• Numéro MDL: MFCD00037000
• Code UNSPSC : 12352204
• ID de substance PubChem : 24277805
• Nomenclature NACRES : NA.32

Propriétés

• Product Name: 1-Methylhistamine dihydrochloride, ≥98% (TLC), powder
• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Solubilité: water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl[H].Cl[H].Cn1cnc(CCN)c1
• InChI: 1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
• Clé InChI: AGXVEALMQHTMSW-UHFFFAOYSA-N
• Informations sur le gène: human ... HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)

Description

Application

1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity.

Actions biochimiques/physiologiques

1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s disease (AD), hypersomnia, and other neurological conditions.

Major metabolite of histamine by histamine N-methyltransferase.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves