M5060

E-4031

≥98% (HPLC), lyophilized powder

• Synonyme(s) : N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
• Formule empirique (notation de Hill) : C₂₁H₂₇N₃O₃S · 2HCl
• CAS Number: 113559-13-0
• Poids moléculaire : 474.44
• Numéro MDL: MFCD01754739
• Code UNSPSC : 12352207
• ID de substance PubChem : 329818000
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: lyophilized powder
• Conditions de stockage: desiccated
• Technique(s): cell culture | embryo: suitable
• Couleur: white
• Solubilité: H₂O: soluble
• Température de stockage: −20°C
• Chaîne SMILES: Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(C)(=O)=O)cc3)n1
• InChI: 1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
• Clé InChI: ZQBNWMFBOSOOLX-UHFFFAOYSA-N

Description

Application

E-4031 has been used as:

• human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
• IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
• IKr blocker in rat ventricular myocytes

Actions biochimiques/physiologiques

E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.

E-4031 selectively blocks hERG K⁺ channels.

Caractéristiques et avantages

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)