M6690

MDL 28170

≥90% (TLC)

• Synonyme(s) : Calpain Inhibitor III
• Formule empirique (notation de Hill) : C₂₂H₂₆N₂O₄
• CAS Number: 88191-84-8
• Poids moléculaire : 382.45
• Numéro MDL: MFCD00798796
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278565
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥90% (TLC)
• Composition: Peptide Content, >90%
• Solubilité: DMSO: 26 mg/mL; H₂O: insoluble; methanol: soluble
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Chaîne SMILES: [H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C
• InChI: 1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1
• Clé InChI: NGBKFLTYGSREKK-ANYOKISRSA-N
• Informations sur le gène: human ... CAPN1(823), CAPN2(824)

Description

Amino Acid Sequence

Z-Val-Phe-al

Application

MDL 28170 has been used as a calpain inhibitor:

• to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest
• to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle
• to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain

Actions biochimiques/physiologiques

MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats. It also shows anti-inflammatory and anti-neurodegenerative properties. MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.

MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H₂O₂ and A23187 treated PC12 cells. γ-secretase-inhibitor.

Potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)