M7894

IgG1, Kappa from murine myeloma

clone MOPC 21, ascites fluid, lyophilized powder

• Synonyme(s) : Mouse IgG1-κ
• Numéro MDL: MFCD00164798
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.46

Propriétés

• Source biologique: mouse
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: ascites fluid
• Clone: MOPC 21, monoclonal
• Forme: lyophilized powder
• Application(s): research pathology
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified

Description

Description générale

The MOPC-21 tumor line that produces mouse IgG1, κ is a mineral oil induced plasmacytoma originated and carried intraperitoneally in BALB/c mice. Immunoglobulins G are made up of two identical light chains and two identical heavy chains, that are covalently connected by interchain disulphide bonds.[1] Mouse IgG is further divided into five classes- IgG1, IgG2a, IgG2b, IgG2c and IgG3.[2]

Application

IgG1, Kappa from murine myeloma has been used:

• in stimulation assay and enzyme-linked immunosorbent assay (ELISA)[3]
• as isotype controls in islet hormone production[4]
• in flow cytometric analysis[5], in cell migration assay[6]
• as control antibody in evaluation of methylation[7]

Actions biochimiques/physiologiques

IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids. It provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.[8]

Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions.[9] IgG helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.[2]

Reconstitution

Reconstitute with 1 mL deionized water.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)