N0258

N-Nitrosodiethylamine

ISOPAC^®

• Synonyme(s) : Diethylnitrosamine
• Formule linéaire : (C₂H₅)₂NNO
• CAS Number: 55-18-5
• Poids moléculaire : 102.14
• Beilstein: 1744991
• Numéro CE : 200-226-1
• Numéro MDL: MFCD00013890
• Code UNSPSC : 12352116
• ID de substance PubChem : 24897417
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Forme: liquid
• pb: 177 °C (lit.)
• Densité: 0.95 g/mL (lit.)
• Chaîne SMILES: CCN(CC)N=O
• InChI: 1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
• Clé InChI: WBNQDOYYEUMPFS-UHFFFAOYSA-N

Description

Application

N-Nitrosodiethylamine (NDEA) has been used as a hepatocarcinogen/DNA damaging agent. It has been used as a calibration standard for gas–liquid chromatography.

Actions biochimiques/physiologiques

N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine. It is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. NDEA is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. It results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Conditionnement

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.

Attention

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Reconstitution

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Informations légales

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H350,H412
• Conseils de prudence: P202 - P264 - P270 - P273 - P280 - P301 + P310
• Classification des risques: Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter