N151

Nisoxetine hydrochloride

solid, ≥98% (HPLC)

• Synonyme(s) : (±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride, LY-94,939
• Formule empirique (notation de Hill) : C₁₇H₂₁NO₂ · HCl
• CAS Number: 57754-86-6
• Poids moléculaire : 307.82
• Numéro MDL: MFCD00153850
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277788
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 20 mg/mL; ethanol: 50 mg/mL
• Chaîne SMILES: Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2
• InChI: 1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
• Clé InChI: LCEURBZEQJZUPV-UHFFFAOYSA-N

Description

Application

Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.

Actions biochimiques/physiologiques

Nisoxetine is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)