N8652

NF 023 hydrate

≥98% (HPLC), solid

• Synonyme(s) : 8,8′-[Carbonylbis(imino-3,1-phenylene carbonylimino)]bis(1,3,5-naphthalene-trisulfonic acid) hexasodium salt hydrate
• Formule empirique (notation de Hill) : C₃₅H₂₀N₄O₂₁S₆ · 6Na · xH₂O
• CAS Number: 104869-31-0
• Poids moléculaire : 1162.88 (anhydrous basis)
• Numéro MDL: MFCD11046019
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278597
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: H₂O: >20 mg/mL
• Chaîne SMILES: O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)c1cc(c2c(NC(=O)c3cccc(NC(=O)Nc4cccc(c4)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c3)ccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O
• InChI: 1S/C35H26N4O21S6.6Na.H2O/c40-33(38-25-7-9-27(63(49,50)51)23-13-21(61(43,44)45)15-29(31(23)25)65(55,56)57)17-3-1-5-19(11-17)36-35(42)37-20-6-2-4-18(12-20)34(41)39-26-8-10-28(64(52,53)54)24-14-22(62(46,47)48)16-30(32(24)26)66(58,59)60;;;;;;;/h1-16H,(H,38,40)(H,39,41)(H2,36,37,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60);;;;;;;1H2/q;6*+1;/p-6
• Clé InChI: FLINBQMOKZJBEC-UHFFFAOYSA-H
• Informations sur le gène: human ... P2RX1(5023), P2RY1(5028), P2RY11(5032), P2RY2(5029)

Description

Application

NF 023 hydrate has been used as an inhibitor of methyltransferases. It has also been used to test its inhibitory effect on human adenovirus type-37 (HAdV-D37) viral infection in human corneal epithelial (HCE) cells.

Actions biochimiques/physiologiques

NF 023 contains six benzene rings and is a suramin analog. It is a potent, competitive, and selective P2X purinoceptor antagonist that aids in discriminating between P2X receptor subtypes.

Caractéristiques et avantages

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Conditionnement

Desiccate

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves