P0122

Pifithrin-μ

≥97% (HPLC), solid

• Synonyme(s) : 2-Phenyl-ethynesulfoanide, PFT-μ
• Formule empirique (notation de Hill) : C₈H₇NO₂S
• CAS Number: 64984-31-2
• Poids moléculaire : 181.21
• Numéro MDL: MFCD00181531
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724568
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Solubilité: DMSO: soluble >10 mg/mL, clear; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: NS(=O)(=O)C#Cc1ccccc1
• InChI: 1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
• Clé InChI: ZZUZYEMRHCMVTB-UHFFFAOYSA-N

Description

Application

Pifithrin-μ has been used:

• to treat microglial cell line to analyse its neuroprotective effect on M1-like and M2-like phenotype
• as heat shock protein (HSP)-70 inhibitor, to treat transfected Marc-145 cells
• to inhibit heat shock cognate 70 (Hsc70) to elucidate heat shock chaperones mouse embryonic stem cells

Actions biochimiques/physiologiques

Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins.

Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.

Pifithrin-μ(PFT-μ) has neuroprotective capabilities against cell death in a preclinical model of hypoxia-ischemia (HI)-induced neonatal encephalopathy. It inhibits nuclear factor-ΙB (NF-ΙB) pathway by inhibiting the interaction of molecular chaperone heat shock protein (HSP)-70 with its substrates.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves