P1246

p30

• CAS Number: 3308-62-1
• Numéro MDL: MFCD01727216
• Code UNSPSC : 12352204
• ID de substance PubChem : 329820082
• Nomenclature NACRES : NA.54

Propriétés

• Produit recombinant: expressed in E. coli
• Niveau de qualité: 200
• Forme: solution
• Température de stockage: −20°C
• Chaîne SMILES: Cl.CN(C)CCOc1ccc2OCCOc2c1
• InChI: 1S/C12H17NO3.ClH/c1-13(2)5-6-14-10-3-4-11-12(9-10)16-8-7-15-11;/h3-4,9H,5-8H2,1-2H3;1H
• Clé InChI: VRCSNYKNBODDIM-UHFFFAOYSA-N

Description

Application

p30 is an endogenous truncated form of p39 that associates with Cdk5 to form Nclk, which regulates neurotransmission, axon guidance, central nervous system (CNS) architecture, and pathogenesis. Therefore, p30 is useful in studying neurodegenerative diseases such as Alzheimer′s, Amyotrophic Lateral Sclerosis, and Parkinson′s Disease.

Actions biochimiques/physiologiques

P30 activates GST-Neuronal cyclin-dependent kinase 5 (Cdk5). It also associates with Cdk5 to form an activated neuronal Cdc2-like kinase (Nclk). Product P1246 is recombinant, from bovine and is expressed in E. coli.

Définition de l'unité

One unit will incorporate 1 picomole of phosphate into histone H1 peptide per minute at pH 7.2 at 30 °C.

Forme physique

p30 is supplied in a solution of 25 mM Tris, pH 7.4, 1 mM DTT, and 30% glycerol. (0.5 μg protein/ 25 ul vial)

Notes préparatoires

Expressed as a GST fusion protein.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids