P1639

Patulin

≥98.0% (HPLC)

• Synonyme(s) : Clavacin, Clavatin, Expansine, Gigantin, Leucopin, Mycoine C3, Terinin, 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
• Formule empirique (notation de Hill) : C₇H₆O₄
• CAS Number: 149-29-1
• Poids moléculaire : 154.12
• Beilstein: 149675
• Numéro CE : 205-735-2
• Numéro MDL: MFCD00005858
• Code UNSPSC : 51102829
• ID de substance PubChem : 24898227
• Nomenclature NACRES : NA.85

Propriétés

• Niveau de qualité: 300
• Essai: ≥98.0% (HPLC)
• Forme: powder
• Solubilité: water: 9-11 mg/mL
• Spectre d'activité de l'antibiotique: fungi
• Mode d’action: cell membrane | interferes
• Température de stockage: −20°C
• Chaîne SMILES: OC1OCC=C2OC(=O)C=C12
• InChI: 1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2
• Clé InChI: ZRWPUFFVAOMMNM-UHFFFAOYSA-N

Description

Description générale

Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It is commonly found in apples. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na⁺-K⁺ dependent ATPase and to induce intra- and intermolecular protein crosslinking.

Application

Patulin has been used:

• to study patulin contamination of bottled wine
• in DNA-damaging activity of patulin in Escherichia coli
• in molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus

Actions biochimiques/physiologiques

Mycotoxin with anti-bacterial, potassium uptake inhibitory, and possibly carcinogenic activities. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na⁺-K⁺ dependent ATPase and to induce intra- and intermolecular protein crosslinking.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300,H315
• Conseils de prudence: P264 - P270 - P280 - P301 + P310 - P302 + P352 - P332 + P313
• Classification des risques: Acute Tox. 2 Oral - Skin Irrit. 2
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves