P2371

Pamidronate disodium salt hydrate

≥95% (NMR), solid

• Synonyme(s) : 3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate
• Formule empirique (notation de Hill) : C₃H₉NO₇P₂Na₂ · xH₂O
• CAS Number: 57248-88-1
• Poids moléculaire : 279.03 (anhydrous basis)
• Numéro CE : 260-647-1
• Numéro MDL: MFCD11045314
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724574
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (NMR)
• Forme: solid
• Couleur: white
• Pf: 300 °C
• Solubilité: H₂O: 28 mg/mL
• Auteur: Novartis
• Température de stockage: 2-8°C
• Chaîne SMILES: O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
• InChI: 1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
• Clé InChI: TVQNUQCYOOJTMK-UHFFFAOYSA-L

Description

Actions biochimiques/physiologiques

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC₅₀ = 200 nM).

Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves