P3246

Pipamperone dihydrochloride

~99% (HPLC), powder

• Synonyme(s) : 1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride, R4050
• Formule empirique (notation de Hill) : C₂₁H₃₀N₃O₂F · 2HCl
• CAS Number: 2448-68-2
• Poids moléculaire : 448.40
• Numéro CE : 219-507-5
• Numéro MDL: MFCD00242980
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724576
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ~99% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Couleur: white
• Solubilité: H₂O: >2.0 mg/mL
• Auteur: Johnson & Johnson
• Chaîne SMILES: Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3
• InChI: 1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H
• Clé InChI: BMXXSXQVMCXGJM-UHFFFAOYSA-N

Description

Application

Pipamperone dihydrochloride may be used:

• as an internal standard in liquid chromatography with coulometric detection
• as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
• as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis

Actions biochimiques/physiologiques

D₂ dopamine receptor antagonist; 5-HT₂ serotonin receptor antagonist; antipsychotic.

Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.

Caractéristiques et avantages

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves