P3755

6-Propyl-2-thiouracil

enzyme inhibitor

• Synonyme(s) : 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine
• Formule empirique (notation de Hill) : C₇H₁₀N₂OS
• CAS Number: 51-52-5
• Poids moléculaire : 170.23
• Beilstein: 130039
• Numéro CE : 200-103-2
• Numéro MDL: MFCD00006041
• Code UNSPSC : 41106305
• ID de substance PubChem : 24898446
• Nomenclature NACRES : NA.51

Propriétés

• Description: enzyme inhibitor
• Niveau de qualité: 200
• Essai: ≥99% (HPLC)
• Forme: powder
• Pf: 218-220 °C (lit.)
• Solubilité: 10% NH₃: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Chaîne SMILES: CCCC1=CC(=O)NC(=S)N1
• InChI: 1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
• Clé InChI: KNAHARQHSZJURB-UHFFFAOYSA-N
• Informations sur le gène: human ... DIO1(1733), TPO(7173)

Description

Description générale

6-Propyl-2-thiouracil or 6-n-Propylthiouracil (PROP) is a compound with a bitter taste.

Application

6-Propyl-2-thiouracil (PROP) has been used to impregnate on disk for PROP taster status studies for sensory characterization in a defined human sample group. It has been used as a screening agent for testing the intensity of taste by labeled magnitude scale (LMS).

6-Propyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, high performance liquid chromatography (HPLC), or gas chromatography.

Actions biochimiques/physiologiques

6-Propyl-2-thiouracil (6-PTU), a potential inhibitor of D1 iodothyronine deiodinase, is involved in the deiodination of iodothyronines. It is an uncompetitive inhibitor of iodothyronine substrates.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H351
• Conseils de prudence: P201 - P301 + P312 + P330 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges