P4365

PJ-34 hydrochloride hydrate

≥98% (HPLC), powder

• Synonyme(s) : PARP Inhibitor VIII, PJ 34 HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₁₇N₃O₂ · HCl · xH₂O
• CAS Number: 344458-15-7
• Poids moléculaire : 331.80 (anhydrous basis)
• Code UNSPSC : 12352200
• ID de substance PubChem : 24898531
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to yellow
• Solubilité: H₂O: 22 mg/mL
• Chaîne SMILES: Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1
• InChI: 1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2
• Clé InChI: YCALIZUKAFUQCH-UHFFFAOYSA-N

Description

Application

PJ-34 hydrochloride hydrate has been used:

• as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
• as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
• as PARP inhibitor in murine MLE-12 epithelial cell line

Actions biochimiques/physiologiques

PJ-34 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor.

PJ-34 is a prototypic poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)