P6628

Pilocarpine nitrate salt

≥98% (HPLC)

• Formule empirique (notation de Hill) : C₁₁H₁₆N₂O₂ · HNO₃
• CAS Number: 148-72-1
• Poids moléculaire : 271.27
• Beilstein: 4171406
• Numéro CE : 205-723-7
• Numéro MDL: MFCD00078497
• Code UNSPSC : 12352200
• ID de substance PubChem : 57654548
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]25/D +83°, c = 10 in H₂O(lit.)
• Couleur: white
• Solubilité: H₂O: 100 mg/mL
• Chaîne SMILES: O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
• Clé InChI: PRZXEPJJHQYOGF-GNAZCLTHSA-N
• Informations sur le gène: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Description

Application

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Actions biochimiques/physiologiques

Nonselective muscarinic acetylcholine receptor agonist.

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Informations sur la sécurité

• Pictogrammes: GHS03,GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H272,H302,H330
• Conseils de prudence: P210 - P220 - P260 - P264 - P301 + P312 - P304 + P340 + P310
• Classification des risques: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2
• Code de la classe de stockage: 5.1B - Oxidizing hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges