P7791

Prazosin hydrochloride

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

• Synonyme(s) : 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride
• Formule empirique (notation de Hill) : C₁₉H₂₁N₅O₄ · HCl
• CAS Number: 19237-84-4
• Poids moléculaire : 419.86
• Beilstein: 4303561
• Numéro CE : 242-903-4
• Numéro MDL: MFCD00058177
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277793
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Prazosin hydrochloride, ≥99.0% (HPLC)
• Niveau de qualité: 100
• Essai: ≥99.0% (HPLC)
• Forme: powder
• Solubilité: H₂O: 0.5 mg/mL; methanol: 6 mg/mL; dilute aqueous acid: insoluble
• Chaîne SMILES: Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
• InChI: 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
• Clé InChI: WFXFYZULCQKPIP-UHFFFAOYSA-N
• Informations sur le gène: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

Description générale

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

Application

Prazosin hydrochloride has been used:

• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
• as an α1-adrenoceptor blocker,administered intragastrically in rats
• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Actions biochimiques/physiologiques

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Caractéristiques et avantages

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Attention

Hygroscopic; light sensitive.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H336,H361fd,H373
• Conseils de prudence: P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• Classification des risques: Repr. 2 - STOT RE 2 - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves