PZ0160

UK-5099

≥98% (HPLC), powder, mitochondrial pyruvate carrier inhibitor

• Synonyme(s) : 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, PF-1005023
• Formule empirique (notation de Hill) : C₁₈H₁₂N₂O₂
• CAS Number: 56396-35-1
• Poids moléculaire : 288.30
• Numéro MDL: MFCD19443867
• Code UNSPSC : 12352200
• ID de substance PubChem : 329823742
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: UK-5099, ≥98% (HPLC)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: yellow to tan
• Solubilité: DMSO: >20 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N
• InChI: 1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
• Clé InChI: BIZNHCWFGNKBBZ-JLHYYAGUSA-N

Description

Application

UK-5099 has been used:

• as a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culture
• in dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophages
• in topical treatment in order to study its effect on hair cycle induction in experimental mice

Actions biochimiques/physiologiques

UK-5099 induces lactate generation.

UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter.

UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter. In rat heart mitochondria, UK-5099 inhibits pyruvate-dependent O₂ consumption with an IC₅₀ of 50 nM.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable