PZ0211

PF-4778574

≥98% (HPLC)

• Synonyme(s) : N-[(3R,4S)-3-[4-(5-Cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl]-2-propanesulfonamide, N-{(3R,4S)-3-[4-(5-Cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl}propane-2-sulfonamide
• Formule empirique (notation de Hill) : C₁₉H₂₂N₂O₃S₂
• CAS Number: 1219633-99-4
• Poids moléculaire : 390.52
• Code UNSPSC : 41106609
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: [S](=O)(=O)(N[C@@H]1[C@H](COCC1)c2ccc(cc2)c3[s]c(cc3)C#N)C(C)C
• InChI: 1S/C19H22N2O3S2/c1-13(2)26(22,23)21-18-9-10-24-12-17(18)14-3-5-15(6-4-14)19-8-7-16(11-20)25-19/h3-8,13,17-18,21H,9-10,12H2,1-2H3/t17-,18+/m1/s1
• Clé InChI: FFAGHPLLBXWCSF-MSOLQXFVSA-N

Description

Application

PF-4778574 may be used as a potentiator of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) in rat cortical neurons.

Actions biochimiques/physiologiques

PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models.

PF-4778574 is a potent AMPA receptor positive allosteric modulator.

Caractéristiques et avantages

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable