R2033

RK-682

≥98% (HPLC)

• Synonyme(s) : (R)-3-Hexadecanoyl-5-hydroxymethyltetronic acid, (R)-4-Hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone
• Formule empirique (notation de Hill) : C₂₁H₃₆O₅
• CAS Number: 150627-37-5
• Poids moléculaire : 368.51
• Numéro MDL: MFCD20488046
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824012
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO, heptane and xylene: ≥8 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: CCCCCCCCCCCCCCCC(=O)C1=C(O)[C@@H](CO)OC1=O
• InChI: 1S/C21H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(23)19-20(24)18(16-22)26-21(19)25/h18,22,24H,2-16H2,1H3/t18-/m1/s1
• Clé InChI: KZTSLHQKWLYYAC-GOSISDBHSA-N

Description

Application

RK-682 has been used:

• as a positive control in high-performance liquid chromatography (HPLC)
• as a reference compound in high-performance liqiud chromatography (HPLC)
• as a pan-protein tyrosine phosphatase non-receptor type (PTPN) inhibitor to study its effects on the activated lymphocytes

Actions biochimiques/physiologiques

RK-682 is a specific and noncompetitive inhibitor of protein tyrosine phosphatase; It inhibited dephosphorylation activity of CD45 and VHR with IC50 54 and 2.0 microM and 4.5 microM against PTP1B.

Specific and noncompetitive inhibitor of protein tyrosine phosphatase.

Caractéristiques et avantages

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable