R9644

Ribavirin

antiviral

• Synonyme(s) : 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
• Formule empirique (notation de Hill) : C₈H₁₂N₄O₅
• CAS Number: 36791-04-5
• Poids moléculaire : 244.20
• Numéro MDL: MFCD00058564
• Code UNSPSC : 12352202
• ID de substance PubChem : 24278685
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Solubilité: water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow
• Spectre d'activité de l'antibiotique: viruses
• Mode d’action: DNA synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
• Clé InChI: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• Informations sur le gène: human ... IMPDH1(3614), IMPDH2(3615)

Description

Description générale

Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.

Chemical structure: nucleoside

Actions biochimiques/physiologiques

Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.

Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase.

Antiviral agent. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase. Used to inhibit purine (GTP pools) biosynthesis at the level of inosine monophosphate (IMP) dehydrogenase and as a precursor to the di- and tri-phosphates which inhibit viral RNA-dependent RNA polymerases.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H341,H360FD
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Muta. 2 - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges