S0441

SB-366791

≥98% (HPLC), powder

• Synonyme(s) : N-(3-Methoxyphenyl)-4-chlorocinnamide
• Formule empirique (notation de Hill) : C₁₆H₁₄NO₂Cl
• CAS Number: 472981-92-3
• Poids moléculaire : 287.74
• Numéro MDL: MFCD01033818
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278690
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear
• Auteur: GlaxoSmithKline
• Chaîne SMILES: COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
• InChI: 1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
• Clé InChI: RYAMDQKWNKKFHD-JXMROGBWSA-N
• Informations sur le gène: human ... TRPV1(7442)

Description

Application

SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:

• to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)
• to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity
• to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)

Actions biochimiques/physiologiques

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.

Vanilloid receptor-1 (TRPV1) antagonist.

Caractéristiques et avantages

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)