S2075

Src Inhibitor-1

≥98% (HPLC)

• Synonyme(s) : 4-(4′-Phenoxyanilino)-6,7-dimethoxyquinazoline, 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine, SKI-1, Src-l1
• Formule empirique (notation de Hill) : C₂₂H₁₉N₃O₃
• CAS Number: 179248-59-0
• Poids moléculaire : 373.40
• Numéro MDL: MFCD01815300
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824504
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
• InChI: 1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
• Clé InChI: DMWVGXGXHPOEPT-UHFFFAOYSA-N

Description

Application

Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies.

Actions biochimiques/physiologiques

Apart from Src kinase, some Src inhibitors also inhibit the activity of Abl kinase, Lck, Csk and Yes proteins and are therefore being explored as viable anti-cancer drug options.

Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor.

Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the "gold standards" for Src kinase inhibition. It has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. Src Inhibitor-1 is a selective, competitive inhibitor of Src family of tyrosine kinases (IC₅₀ = 44 nM and 88 nM for Src and Lck, respectively). Src Inhibitor-1 Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC₅₀ = 0.32 μM and 30 μM, respectively).

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3