S4568

SCH 58261

≥98% (HPLC), solid

• Synonyme(s) : 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
• Formule empirique (notation de Hill) : C₁₈H₁₅N₇O
• CAS Number: 160098-96-4
• Poids moléculaire : 345.36
• Numéro MDL: MFCD00933778
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824547
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: off-white
• Solubilité: DMSO: soluble >10 mg/mL; H₂O: insoluble
• Chaîne SMILES: Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5
• InChI: 1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
• Clé InChI: UTLPKQYUXOEJIL-UHFFFAOYSA-N

Description

Application

SCH 58261 was used to block A2α adenosine receptor to study the signaling by prostatic acid phosphatase in neurons.⁴

Actions biochimiques/physiologiques

A_2A adenosine receptor antagonist.

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.

Caractéristiques et avantages

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)