S7201

SR-46349 hemifumarate salt

≥98% (HPLC)

• Synonyme(s) : 4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt, Eplivanserin hemifumarate salt, SR-46349B
• Formule empirique (notation de Hill) : C₁₉H₂₁FN₂O₂ · 0.5 C₄H₄O₄
• CAS Number: 130580-02-8
• Poids moléculaire : 386.42
• Numéro MDL: MFCD12546335
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824579
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: white to off-white
• Solubilité: DMSO: ≥10 mg/mL
• Auteur: Sanofi Aventis
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(=O)\C=C\C(O)=O.CN(C)CCO\N=C(\C=C\c1ccc(O)cc1)c2ccccc2F.CN(C)CCO\N=C(\C=C\c3ccc(O)cc3)c4ccccc4F
• InChI: 1S/2C19H21FN2O2.C4H4O4/c2*1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15;5-3(6)1-2-4(7)8/h2*3-12,23H,13-14H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b2*12-9+,21-19-;2-1+
• Clé InChI: RNLKLYQQDLHHBH-ABDBJYMXSA-N
• Informations sur le gène: human ... HTR2A(3356)

Description

Application

SR-46349 hemifumarate salt may be used in cell signaling studies.

Actions biochimiques/physiologiques

ASTAR (Antagonist of Serotonin 5HT2A Receptors).

SR-46349 is an antagonist of 5-HT (2A/2C) receptor and increases the release of dopamine by medial prefrontal cortex in rats.¹ It increases the signal transduction induced by 5-HT₂ receptor by binding with high affinity.² SR-46349 inhibits the aggregation of rabbit and human platelets in response to serotonin.³

Caractéristiques et avantages

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H410
• Conseils de prudence: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable