S7771

(S)-(−)-Sulpiride

≥98% (titration)

• Synonyme(s) : (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, Levosulpiride
• Formule empirique (notation de Hill) : C₁₅H₂₃N₃O₄S
• CAS Number: 23672-07-3
• Poids moléculaire : 341.43
• Numéro MDL: MFCD00055220
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278709
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (titration)
• Pf: 183-186 °C (lit.)
• Auteur: Sanofi Aventis
• Température de stockage: 2-8°C
• Chaîne SMILES: CCN1CCC[C@H]1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O
• InChI: 1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1
• Clé InChI: BGRJTUBHPOOWDU-NSHDSACASA-N
• Informations sur le gène: human ... DRD2(1813), DRD3(1814) ; rat ... Adra1a(29412), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595)

Description

Application

(S)-(−)-Sulpiride was used to study the effect of dopamine D₂ receptor function on activation of KCNQ potassium channels¹⁰ and on depression-like behavior in ovariectomized female rats.¹¹

Actions biochimiques/physiologiques

(S)-(−)-Sulpiride or Levosulpiride blocks the inhibitory enteric D₂ receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.^7,8 Since dopamine controls human sexual function, (S)-(−)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.⁹

D₂ dopamine receptor antagonist; antipsychotic.

Caractéristiques et avantages

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable