S8251

Succinylcholine chloride dihydrate

98.0-102.0%, solid

• Synonyme(s) : Bis(trimethylammonioethyl) succinate chloride, Succinyldicholine dichloride
• Formule linéaire : [(CH₃)₃NCH₂CH₂OCOCH₂]₂Cl₂ · 2H₂O
• CAS Number: 6101-15-1
• Poids moléculaire : 397.34
• Beilstein: 3922827
• Numéro CE : 200-747-4
• Numéro MDL: MFCD00150564
• Code UNSPSC : 41116107
• ID de substance PubChem : 24277873
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: 98.0-102.0%
• Forme: solid
• Couleur: white
• Solubilité: H₂O: complete 100 mg/ml, clear to slightly hazy, colorless; H₂O: soluble (unstable at pH > 9.)
• Auteur: Novartis
• Chaîne SMILES: O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
• InChI: 1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2
• Clé InChI: FFSBEIRFVXGRPR-UHFFFAOYSA-L

Description

Application

Succinylcholine chloride dehydrate was used to study the mechanism of gating of Cys loop receptors in Xenopus laevis.^4,5

Actions biochimiques/physiologiques

Cholinergic antagonist which induces a long-lasting depolarization of the acetylcholine neuron membrane; neuromuscular blocking agent.

Succinylcholine is a cholinergic antagonist and a neuromuscular blocking agent. It induces depolarization of acetylcholine receptors on the muscle membrane and efflux of potassium from the muscle that leads to hypokalemia in individuals with upregulated expression of acetylcholine receptors.³

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Reconstitution

Solutions may be stored for several days at 4 °C.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P301 + P310
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)