S8688

SR 59230A

≥98% (HPLC), powder, β3-Adrenoceptor antagonist

• Synonyme(s) : 3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt
• Formule empirique (notation de Hill) : C₂₁H₂₇NO₂ · C₂H₂O₄
• CAS Number: 174689-39-5
• Poids moléculaire : 415.48
• Numéro MDL: MFCD00940163
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278715
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: SR 59230A, ≥98% (HPLC), powder
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: DMSO: >10 mg/mL; H₂O: insoluble
• Auteur: Sanofi Aventis
• Chaîne SMILES: OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23
• InChI: 1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
• Clé InChI: XTBQNQMNFXNGLR-MKSBGGEFSA-N
• Informations sur le gène: human ... ADRB3(155)

Description

Application

SR 59230A was used in the identification of β-adrenoceptors in rat aorta.³ It was tested as a potential therapeutic agent in improving cardiac function in rat model of heart failure.⁴

Actions biochimiques/physiologiques

SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.¹ It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.²

Caractéristiques et avantages

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)