S9576

SR8278

≥98% (HPLC)

• Synonyme(s) : 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
• Formule empirique (notation de Hill) : C₁₈H₁₉NO₃S₂
• CAS Number: 1254944-66-5
• Poids moléculaire : 361.48
• Numéro MDL: MFCD18782736
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824626
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: lyophilized powder
• Couleur: white
• Solubilité: DMSO: ≥30 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3
• InChI: 1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
• Clé InChI: UIEBLUZPSFAFOC-UHFFFAOYSA-N

Description

Application

SR8278 has been used as a nuclear receptor subfamily 1, group D, member 1 (NR1D1) antagonist to study its effects on starvation-induced macrophages.

SR8278 was used as rev-erb alpha antagonist to study the regulation of glucagon secretion in mouse pancreatic alpha cells¹ and beta cells.²

Actions biochimiques/physiologiques

SR8278 is a Nuclear Heme Receptor REV-ERB antagonist.

SR8278 is a Nuclear Heme Receptor REV-ERB antagonist. REV-ERBα plays a critical role in regulation of the circadian rhythm by repressing target gene activities. Additionally, REV-ERBα has been shown to regulate metabolic processes including lipid and glucose metabolism. SR8278 blocks the ability of the synthetic agonist GSK4112 to enhance REV-ERBα-dependent repression and stimulates the expression of REV-ERBα target genes involved in gluconeogenesis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable