SAB4502023

Anti-NOTCH4 (Cleaved-Val¹⁴³²), C-Terminal antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : INT3, NOTC4, NOTCH3, neurogenic locus notch 4, notch 4
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 59 kDa
• Espèces réactives: human
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:1000; western blot: 1:500-1:1000
• Numéro d'accès NCBI: Q99466
• Numéro d'accès UniProt: Q99466
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: proteolytically cleaved (Val1432)
• Informations sur le gène: human ... NOTCH4(4855)

Description

Description générale

Anti-NOTCH4 (Cleaved-Val¹⁴³²) antibody detects endogenous levels of fragment of activated NOTCH4 (Cleaved-Val¹⁴³²) protein.

The NOTCH4 gene is mapped to human chromosome 6p21.32.

Immunogène

The antiserum was produced against synthesized peptide derived from human NOTCH4.

Immunogen Range: 1401-1450

Actions biochimiques/physiologiques

The NOTCH4 gene is associated with the process of angiogenesis and homeostasis during developmental process. NOTCH4 plays a role in Notch signaling pathway which mediates epithelial cell and stem cell homeostasis. Notch signaling pathway is induced in a number of cancer types including colon, breast, pancreatic, cervical, head and neck, renal carcinoma, prostate cancer, Large-cell and Hodgkin lymphomas.Thus, NOTCH4 is known to participate in tumorigenesis. This gene is involved in the development of central nervous system and controls neuronal maturation. Mutations in the gene might be associated with schizophrenia.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable