SAB4504676

Anti-phospho-VE-Cadherin (pTyr⁷³¹) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-7B4, Anti-CD144
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 87 kDa
• Espèces réactives: human, rat, mouse
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Numéro d'accès NCBI: P33151
• Numéro d'accès UniProt: P33151
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pTyr731)
• Informations sur le gène: human ... CDH5(1003)

Description

Description générale

Cadherin 5 (CDH5) is encoded by the gene mapped to long arm of human chromosome 16. The encoded protein is expressed in endothelial cells, but it is absent in normal epithelium.

Immunogène

The antiserum was produced against synthesized peptide derived from human VE-Cadherin around the phosphorylation site of Tyr731.

Immunogen Range: 697-746

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Actions biochimiques/physiologiques

Cadherin 5 (CDH5) plays an essential role in various cellular processes, such as regulation of cell adhesion, cell proliferation, cell survival, cell shape, cell motility, modulation of signaling pathways and transcriptional gene regulation. Cdh5/VE(vascular endothelial)-cadherin is a core component of endothelial adherens junction, which plays a vital role in angiogenic sprouting by enhancing cell migration and cell elongation. CDH5 expressed in glioblastoma multiforme (GBM), facilitates the transdifferentiation of glioblastoma stem-like cells (GSCs) to endothelial cells and to form blood vessels, under hypoxia condition. VE-cadherin induces endothelial cell-cell adhesion at adherens junctions (AJs). CDH5 gene knockout results in loss of cell polarity and modification in vascular lumenal structure. CDH5 inhibits the synthesis of CDH2 (also known as N-cadherin) in the endothelium.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable