SAB5300177

Anti-SOX2 Antibody

mouse monoclonal, 10F10

• Synonyme(s) : Sox-2, Sox2, lcc, ysb
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Product Name: Monoclonal Anti-SOX2 antibody produced in mouse, clone 10F10, ascites fluid
• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: ascites fluid
• Type de produit anticorps: primary antibodies
• Clone: 10F10, monoclonal
• Poids mol.: 34 kDa
• Espèces réactives: human
• Technique(s): direct ELISA: 1:10,000; immunohistochemistry: 1:200-1:1,000; indirect immunofluorescence: 1:200-1:1,000; western blot: 1:500-1:2,000
• Isotype: IgG1
• Numéro d'accès UniProt: P48431
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... SOX2(20674)

Description

Description générale

SOX2 (sex-determining region Y-box 2) is a transcription factor consisting of 317 amino acids. It has an HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3.

Immunogène

Purified recombinant fragment of human SOX2 expressed in E.coli.
Mouse monoclonal antibody raised against SOX2

Application

Monoclonal Anti-SOX2 antibody has been used as a core pluripotency factor to regulate stem cell pluripotency.

Actions biochimiques/physiologiques

SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.

Forme physique

Ascitic fluid containing 0.03% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable