Accéder au contenu
MilliporeSigma

Passer à

SAB5702749

Sigma-Aldrich

Anti-CYP2D6 Antibody, clone 1X3F0, Rabbit Monoclonal

Synonyme(s) :

CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aider

Source biologique

rabbit

Niveau de qualité

Matériaux

colorless

Clone

1X3F0, monoclonal

Forme

liquid

Poids mol.

50 kDa

Espèces réactives

rat, rat, human

Concentration

0.8mg/mL

Technique(s)

immunofluorescence: 1:50 - 1:200
western blot: 1:500 - 1:2000

Couleur

colorless

Description générale

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Immunogène

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Recombinant fusion protein containing a sequence corresponding to amino acids 341-497 of human CYP2D6 (P10635).

Application

WB, IF/ICC

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1


Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

Si vous avez besoin d'assistance, veuillez contacter Service Clients

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

E Berman et al.
Carbohydrate research, 113(1), 141-150 (1983-02-16)
As a prelude to studies using bovine N-acetylglucosaminide-beta-(1 leads to 4)-galactosyltransferase to label membrane-surface glycoproteins with isotopically enriched D-galactose, the structural specificity of the enzymic reaction with water-soluble, hen ovalbumin has been examined. The enzyme-catalyzed transfer of D-galactose from UDP-D-galactose
J C Fredenburgh et al.
The Journal of biological chemistry, 267(36), 26150-26156 (1992-12-25)
Plasminogen, the zymogen form of the fibrinolytic enzyme plasmin, is known to undergo plasmin-mediated modification in vitro. The modified form, Lys-plasminogen, is superior to the native Glu-plasminogen in fibrin binding and as a substrate for activation by tissue-type plasminogen activator
P Kilzer et al.
Microvascular research, 30(3), 270-285 (1985-11-01)
A new method is described for assessing changes in vascular permeation by albumin in multiple tissues of the same animal in response to intravascular injection of vasoactive agents. Following intravenous injection of 51Cr-RBC, 125I-BSA, and 57Co-EDTA, a test substance (i.e.
The effect of trypsin treatment on rabbit muscle phosphofructokinase.
K Emerk et al.
Archives of biochemistry and biophysics, 164(1), 233-240 (1974-09-01)
B P Hills et al.
International journal of food microbiology, 36(2-3), 187-198 (1997-05-20)
The survival of Salmonella Typhimurium LT2 in randomly packed beds of glass beads, microporous silica particles and Sephadex microspheres is examined. It is shown that the decrease in the percentage cell recovery in these porous materials at reduced water content

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique