SAB6010054

Anti-phospho-PAK1/PAK2/PAK3 (S144+S141+S139) antibody, clone 3H12, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• Synonyme(s) : Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-3, PAK3, OPHN3
• Code UNSPSC : 12352203

Propriétés

• Produit recombinant: expressed in HEK 293 F cells
• Niveau de qualité: 100
• Conjugué: unconjugated
• Type de produit anticorps: primary antibodies
• Clone: 3H12, recombinant monoclonal
• Forme: liquid
• Poids mol.: 150 kDa
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Concentration: 0.53mg/ml
• Technique(s): ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• Isotype: IgG
• Numéro d'accès UniProt: O75914/Q13153/Q13177
• Conditions d'expédition: wet ice
• Température de stockage: -10 to -25°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer144+pSer141+pSer139)

Description

Description générale

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

Immunogène

A synthesized peptide derived from human Phospho-PAK1/PAK2/PAK3 (S144+S141+S139)

Séquence

YM-pS-FT

Forme physique

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stockage et stabilité

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable