SBR00011

Clarithromycin, Ready Made Solution

50 mg/mL in DMSO

• Synonyme(s) : 6-O-methyl erythromycin
• Formule empirique (notation de Hill) : C₃₈H₆₉NO₁₃
• CAS Number: 81103-11-9
• Poids moléculaire : 747.95
• Numéro MDL: MFCD00865140
• Code UNSPSC : 51102829
• ID de substance PubChem : 329824644
• Nomenclature NACRES : NA.85

Propriétés

• Description: Ready Made Solution
• Niveau de qualité: 200
• Forme: liquid
• Conditions de stockage: dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
• Concentration: 50 mg/mL in DMSO
• Couleur: colorless to faint yellow
• Spectre d'activité de l'antibiotique: Gram-positive bacteria
• Mode d’action: protein synthesis | interferes
• Température de stockage: −20°C
• Chaîne SMILES: N([C@@H]1[C@H]([C@@H](O[C@@H](C1)C)O[C@@H]2[C@H]([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C(=O)[C@@H](C[C@]2(OC)C)C)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O)(C)C
• InChI: 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
• Clé InChI: AGOYDEPGAOXOCK-KCBOHYOISA-N

Description

Description générale

Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.

Application

Clarithromycin may be used for-

• the study of the effects of clarithromycin on rate-dependent changes in QT, T_p-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
• the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
• the study of the synergism of NAB741 with clarithromycin in microtiter plates.

Actions biochimiques/physiologiques

Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.

Conditionnement

2ML

Stockage et stabilité

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 188.6 °F
• Point d'éclair (°C): 87 °C