SBR00076

Baricitinib

≥98% (HPLC), powder

• Synonyme(s) : INCB 028050, LY 3009104
• Formule empirique (notation de Hill) : C₁₆H₁₇N₇O₂S
• CAS Number: 1187594-09-7
• Poids moléculaire : 371.42
• Code UNSPSC : 51101500

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white
• Mode d’action: enzyme | inhibits
• Température de stockage: 2-8°C
• Chaîne SMILES: CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
• InChI: InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
• Clé InChI: XUZMWHLSFXCVMG-UHFFFAOYSA-N

Description

Description générale

Baricitinib is an antibiotic which belongs to a class of compound called known as Janus kinase (JAK) inhibitors. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways.

Application

Baricitinib has been studied for its ability to inhibit Janus kinases (JAKs), which play a crucial role in the signaling pathways involved in inflammation and immune responses. JAK inhibitors like Baricitinib have potential applications in the treatment of a variety of autoimmune and inflammatory diseases.

Actions biochimiques/physiologiques

Baricitinib inhibits the activity of JAK enzymes, which are involved in cytokine signaling, leading to the suppression of inflammation and immune activation. Specifically, baricitinib inhibits JAK1 and JAK2 enzymes, which are associated with the signaling of different cytokines such as interleukin-6 (IL-6), interferon gamma (IFN-gamma), and granulocyte-macrophage colony-stimulating factor (GM-CSF). By inhibiting JAK enzymes, baricitinib reduces the activity of these cytokines and suppresses inflammation and immune activation.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H335,H360FD,H372
• Conseils de prudence: P202 - P260 - P264 - P271 - P280 - P308 + P313
• Classification des risques: Repr. 1B - STOT RE 1 - STOT SE 3
• Organes cibles: Blood,Bone marrow,lymphatic system, Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable