SML0070

Salsalate

≥98% (HPLC)

• Synonyme(s) : 2-(2-Hydroxybenzoyl)oxybenzoic acid, 2-Hydroxybenzoic acid 2-carboxyphenyl ester, disalicylic acid, salicyloxysalicylic acid, salicylsalicylic acid
• Formule empirique (notation de Hill) : C₁₄H₁₀O₅
• CAS Number: 552-94-3
• Poids moléculaire : 258.23
• Numéro CE : 209-027-4
• Numéro MDL: MFCD00020252
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825134
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥15 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: OC(=O)c1ccccc1OC(=O)c2ccccc2O
• InChI: 1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
• Clé InChI: WVYADZUPLLSGPU-UHFFFAOYSA-N

Description

Application

Salsalate was used to study the effect on palmitate-induced insulin resistance and hepatic steatosis in obese rats.

Actions biochimiques/physiologiques

NSAID; Nonacetylated aspirin analog

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319,H361d,H412
• Conseils de prudence: P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable