SML0076

Zoniporide hydrochloride hydrate

≥98% (HPLC)

• Synonyme(s) : N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate
• Formule empirique (notation de Hill) : C₁₇H₁₆N₆O · xHCl · yH₂O
• CAS Number: 241800-98-6
• Poids moléculaire : 320.35 (anhydrous free base basis)
• Numéro MDL: MFCD04113213
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825138
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: H₂O: 2 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
• InChI: 1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
• Clé InChI: UCIJUEGJEFJRMP-UHFFFAOYSA-N

Description

Application

Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.

Zoniporide hydrochloride hydrate may be used in Na⁺/H⁺-mediated cell signaling studies.

Actions biochimiques/physiologiques

Potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1)

Zoniporide is a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1). IC₅₀ = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na⁺ update with IC₅₀ of 14 nM.

Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable