SML0084

IM-12

≥98% (HPLC)

• Synonyme(s) : 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• Formule empirique (notation de Hill) : C₂₂H₂₀FN₃O₂
• CAS Number: 1129669-05-1
• Poids moléculaire : 377.41
• Numéro MDL: MFCD20527313
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825145
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: yellow-orange
• Solubilité: DMSO: ≥9 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CN1C(=O)C(NCCc2ccc(F)cc2)=C(C1=O)c3c(C)[nH]c4ccccc34
• InChI: 1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
• Clé InChI: ZKJAZFUFPPSFCO-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

GSK-3β inhibitor

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation resulting in an increase of neuronal cells. It has an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable