SML0127

Longdaysin

≥98% (HPLC)

• Synonyme(s) : 9-isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
• Formule empirique (notation de Hill) : C₁₆H₁₆F₃N₅
• CAS Number: 1353867-91-0
• Poids moléculaire : 335.33
• Numéro MDL: MFCD20527323
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825177
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥15 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C)N(C=N1)C2=C1C(NCC3=CC(C(F)(F)F)=CC=C3)=NC=N2
• InChI: 1S/C16H16F3N5/c1-10(2)24-9-23-13-14(21-8-22-15(13)24)20-7-11-4-3-5-12(6-11)16(17,18)19/h3-6,8-10H,7H2,1-2H3,(H,20,21,22)
• Clé InChI: REKSFCCYDQMSIN-UHFFFAOYSA-N

Description

Application

Longdaysin may be used to study cell signaling that regulate the circadian clock and behavior.

Actions biochimiques/physiologiques

Longdaysin inhibits CK1, ERK2, and CDK7 kinases in low mM concentrations. The activity of longdaysin results in a lengthening of circadian periods in cell based and in vivo systems. Transgenic zebrafish harboring a per3-luc reporter gene displayed a 10 hour lengthening of circadian period when treated with longdaysin. Longdaysin reduces the phosphorylation of PER1 the regulator of molecular clock function and manipulates the circadian clock.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H315,H319,H335,H361d
• Conseils de prudence: P202 - P261 - P264 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable