SML0150

Tolcapone

≥98% (HPLC)

• Synonyme(s) : 3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone, Ro 40-7592
• Formule empirique (notation de Hill) : C₁₄H₁₁NO₅
• CAS Number: 134308-13-7
• Poids moléculaire : 273.24
• Numéro MDL: MFCD00866569
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825198
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: yellow
• Solubilité: DMSO: ≥15 mg/mL
• Auteur: Roche
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+]([O-])=O
• InChI: 1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3
• Clé InChI: MIQPIUSUKVNLNT-UHFFFAOYSA-N
• Informations sur le gène: human ... COMT(1312)

Description

Application

Tolcapone may be used in COMT-mediated cell signaling studies.
Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.

Actions biochimiques/physiologiques

Inhibition of catechol-O-methyltransferase by tolcapone increases the half-life and bioavailabilty of levodopa. It therefore is an effective adjunctive therapy in patients with Parkinson′s disease with motor response fluctuations.

Orally active catechol-O-methyltransferase (COMT) inhibitor: inhibits both central and peripheral COMT.

Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits both central and peripheral COMT. Tolcapone crosses the blood-brain barrier, and has been used for L-DOPA adjunct therapy in the treatment of Parkinson′s Disease.

Caractéristiques et avantages

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H400
• Conseils de prudence: P273 - P391 - P501
• Classification des risques: Aquatic Acute 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable