SML0238

WEB2086

≥98% (HPLC)

• Synonyme(s) : 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone, Apafant, WEB 2086BS
• Formule empirique (notation de Hill) : C₂₂H₂₂ClN₅O₂S
• CAS Number: 105219-56-5
• Poids moléculaire : 455.96
• Numéro MDL: MFCD00865271
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825250
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 10 mg/mL (clear solution)
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1nnc2CN=C(c3ccccc3Cl)c4cc(CCC(=O)N5CCOCC5)sc4-n12
• InChI: 1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
• Clé InChI: JGPJQFOROWSRRS-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

WEB 2086 inhibits PAF mediated chemotaxis and leukotriene C4 production in eosinophils. It prevents surge in airway resistance and cardiovascular side effects mediated by PAF inhalation.

WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist (IC₅₀ = 16 nM). WEB2086 inhibits the proliferation of tumor cells and slows tumor growth in xenograft tumor models, and has been shown to inhibit angiogenesis.

WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist.

Caractéristiques et avantages

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable