SML0283

Amorolfine hydrochloride

≥98% (HPLC)

• Synonyme(s) : (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride, Ro 14-4767/002
• Formule empirique (notation de Hill) : C₂₁H₃₅ON · HCl
• CAS Number: 78613-38-4
• Poids moléculaire : 353.97
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825291
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: ≥5 mg/mL (warmed)
• Température de stockage: room temp
• Chaîne SMILES: Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
• InChI: 1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
• Clé InChI: XZKWIPVTHGWDCF-KUZYQSSXSA-N

Description

Application

Amorolfine hydrochloride has been used as an antifungal agent.

Actions biochimiques/physiologiques

Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.

Amorolfine hydrochloride is a potential for treating onychomycosis infected nails by topical application. A 5% solution combination with fluconazole is effective on sensitive fungus in fingernail onychomycosis.

Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H411
• Conseils de prudence: P264 - P273 - P280 - P301 + P312 - P302 + P352 - P332 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable