SML0287

680C91

≥98% (HPLC)

• Synonyme(s) : 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl)-1H-indole
• Formule empirique (notation de Hill) : C₁₅H₁₁FN₂
• CAS Number: 163239-22-3
• Poids moléculaire : 238.26
• Numéro MDL: MFCD20926361
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825295
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: ≥10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1
• InChI: 1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+
• Clé InChI: YBSDQTBCNYWBMX-ONEGZZNKSA-N

Description

Application

680C91 has been used:

• as a tryptophan 2,3 dioxygenase (TDO) inhibitor to study its effects on the pigmentation in Doryteuthis pealeii embryos
• as a TDO inhibitor to study its effects on esophageal squamous cell carcinoma in xenograft tumor assay
• as a tryptophan 2,3 dioxygenase 2 (TDO2) inhibitor to study its effects on toxic fragment formation in human embryonic kidney cells

Actions biochimiques/physiologiques

680C91 is a potent inhibitor of the enzyme tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin. Kynurenin has recently been identified as an endogenous lignd of the arylhydrocarbon receptor (AHR). TDO is highly expressed in glioma cells, and contributes to AHR-mediated glioma cell survival and suppression of anti-tumor immune responses.

680C91 is a potent inhibitor of the enzyme tryptophan 2,3-dioxygenase (TDO).

680C91 shows no inhibitory effects against monoamine oxidase A and B, indoleamine 2,3-dioxygenase and serotonin (5-HT) uptake, and 5-HT_1A,_1D,_2A, and _2C receptors.

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H318
• Conseils de prudence: P280 - P305 + P351 + P338
• Classification des risques: Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable