SML0364

RAD51 Inhibitor B02

≥98% (HPLC)

• Synonyme(s) : 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
• Formule empirique (notation de Hill) : C₂₂H₁₇N₃O
• CAS Number: 1290541-46-6
• Poids moléculaire : 339.39
• Numéro MDL: MFCD03294274
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825366
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to dark brown
• Solubilité: DMSO: ≥5 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4
• InChI: 1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
• Clé InChI: GEKDQXSPTHHANP-OUKQBFOZSA-N

Description

Application

RAD51 Inhibitor B02 has been used:

• to test its effect on the polar body extrusion (PBE) rate in porcine oocytes
• for RAD51 inhibition in porcine embryos
• as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)

Actions biochimiques/physiologiques

B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable