SML0370

Kartogenin

≥98% (HPLC)

• Synonyme(s) : 2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI), KGN
• Formule empirique (notation de Hill) : C₂₀H₁₅NO₃
• CAS Number: 4727-31-5
• Poids moléculaire : 317.34
• Numéro MDL: MFCD00560510
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825371
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Solubilité: DMSO: >15 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O
• InChI: 1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
• Clé InChI: SLUINPGXGFUMLL-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes.

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.

Kartogenin is a small heterocyclic compound. It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3