SML0379

Nodinitib-1

≥98% (HPLC)

• Synonyme(s) : 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine, CID-1088438, ML130
• Formule empirique (notation de Hill) : C₁₄H₁₃N₃O₂S
• CAS Number: 799264-47-4
• Poids moléculaire : 287.34
• Numéro MDL: MFCD04322367
• Code UNSPSC : 51111800
• ID de substance PubChem : 329825379
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: NC1=NC2=C(N1S(C3=CC=C(C)C=C3)(=O)=O)C=CC=C2
• InChI: 1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
• Clé InChI: SRFABRWQVPCPRG-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2.

Nodinitib-1 is a selective inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable